Thursday, September 10th, 2015
| Time | Away Team | Pts | Spread | Home Team | Pts | Spread | O/U | |
|---|---|---|---|---|---|---|---|---|
| 8:30 pm | Pittsburgh Steelers | – | +2.5 (-113) | New England Patriots | – | -2.5 (-107) | 48.5 |
Sunday, September 13th, 2015
| Time | Away Team | Pts | Spread | Home Team | Pts | Spread | O/U | |
|---|---|---|---|---|---|---|---|---|
| 1:00 pm | Green Bay Packers | – | -5 (-113) | Chicago Bears | – | +5 (-107) | 50 | |
| 1:00 pm | Kansas City Chiefs | – | +1.5 (-105) | Houston Texans | – | -1.5 (-115) | 42 | |
| 1:00 pm | Cleveland Browns | – | +3 (-109) | New York Jets | – | -3 (-111) | 41 | |
| 1:00 pm | Indianapolis Colts | – | -2 (-113) | Buffalo Bills | – | +2 (-107) | 47 | |
| 1:00 pm | Miami Dolphins | – | -2.5 (-119) | Washington Redskins | – | +2.5 (-101) | 44 | |
| 1:00 pm | Carolina Panthers | – | -4 (-110) | Jacksonville Jaguars | – | +4 (-110) | 42.5 | |
| 1:00 pm | Seattle Seahawks | – | -3 (-118) | St. Louis Rams | – | +3 (-102) | 43 | |
| 4:05 pm | New Orleans Saints | – | +2.5 (+108) | Arizona Cardinals | – | -2.5 (-128) | 47 | |
| 4:05 pm | Detroit Lions | – | +1.5 (+102) | San Diego Chargers | – | -1.5 (-122) | 45.5 | |
| 4:25 pm | Tennessee Titans | – | +3 (+102) | Tampa Bay Buccaneers | – | -3 (-122) | 42 | |
| 4:25 pm | Cincinnati Bengals | – | -3.5 (-107) | Oakland Raiders | – | +3.5 (-113) | 44 | |
| 4:25 pm | Baltimore Ravens | – | +4.5 (-115) | Denver Broncos | – | -4.5 (-105) | 52 | |
| 8:30 pm | New York Giants | – | +6 (-115) | Dallas Cowboys | – | -6 (-105) | 49.5 |
Monday, September 14th, 2015
| Time | Away Team | Pts | Spread | Home Team | Pts | Spread | O/U | |
|---|---|---|---|---|---|---|---|---|
| 7:10 pm | Philadelphia Eagles | – | -1 (-106) | Atlanta Falcons | – | +1 (-114) | 53 | |
| 10:20 pm | Minnesota Vikings | – | +3 (-122) | San Francisco 49ers | – | -3 (+102) | 41 |