If familiarity breeds contempt, there should be animosity aplenty on Sunday when the Indianapolis Colts and the Houston Texans meet at NRG Stadium.

ABOUT THE COLTS (2-3): Luck has thrown for 10 touchdowns against only three interceptions while tying for fourth in the league with 1,469 yards passing, but he also has been sacked an NFL-high 20 times behind Indianapolis’ shaky offensive line. “You don’t want your quarterback hit. Period,” Colts coach Chuck Pagano said. “We’re trying to do everything possible to make sure that doesn’t happen and limit that. He knows that and everybody knows that.” T.Y. Hilton has a touchdown pass in each of the last three games, hauling in 25 of his 35 receptions during that span, including 10 for 171 yards last week. Indianapolis ranks 30th overall (410.6 yards) in total defense an allows 29.6 points per game.

ABOUT THE TEXANS (3-2): Houston invested heavily in a pair of free agents in quarterback Brock Osweiler and running back Lamar Miller, but it has yet to reap the dividends. Osweiler, who replaced an injured Peyton Manning with Denver last season, has more interceptions (seven) than touchdown passes (six) while completing only 58 percent of his passes and posting a quarterback rating of 70.6. Miller has provided more bang for the bucks, rushing for at least 80 yards in each of the first four games, but he was held to 20 yards last week and has yet to find the end zone. Despite the lost of star lineman J.J. Watt, the Texans ranked fifth overall in total defense and are No. 1 against the pass (181.0 yards per game).

currently has the Texans listed as 3-point favorites versus the Colts, while the game’s total is sitting at 48.

The Texans were a 31-13 loser in their most recent outing on the road against the Vikings. They failed to cover the +6-point spread as underdogs, while the total score (44) made winners of OVER bettors.

Indianapolis was a 29-23 winner in its last match at home against the Bears. They covered the -3.5-point spread as favorites, while the total score of 52 sent OVER bettors to the payout window.

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Indianapolis:
Team record: 2-3 SU,2-3 ATS
The total has gone OVER in 5 of Indianapolis’s last 6 games
Indianapolis is 1-4 ATS in its last 5 games on the road
Indianapolis is 1-4 SU in its last 5 games on the road

Houston:
Team record: 3-2 SU,3-2 ATS
Houston is 6-3 ATS in its last 9 games
Houston is 6-3 SU in its last 9 games
The total has gone UNDER in 5 of Houston’s last 7 games

Next up:
Indianapolis at Tennessee Sunday, October 23
Houston at Denver Monday, October 24